Diabetes And Insulin Signaling Case Study Answer Key

Specific pathway example in the context of insulin signaling a signaling effector called irs1 coordinates many different signals. The case is designed in the interrupted format and has three parts that could be used either as homework or as an in class activity. This case study uses insulin signaling and the pathological case of diabetes as a lens through which students will learn general signaling mechanisms like kinase cascades and second messenger pathways.

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It allows researchers to identify the portions in the insulin signaling pathway that may have been altered due to diabetes.

Diabetes and insulin signaling case study answer key. How could the study of insulin signaling help people with diabetes. The quantity of land that is needed to feed a vegan is tons a lot less than to develop the crops to feed a meat eater and dairy client. Type 2 diabetes occurs as a result of continuous insulin signaling due to genetics poor diet obesity and lack of exercise. Irs1 binds to the insulin receptor and activates the mapk kinase cascade.

He primary problem faced by those with type 2 diabetes is insulin resistance their cells no longer respond accordingly to an increase in blood insulin. How could the study of insulin signaling help people with diabetes. Doug is 47 year old man admitted to your medical unit with an ulceration on his right foot. He tells you that he takes nph humulin r insulin 40 units every morning and regular humulin r insulin with each meal and at bedtime.

The study would be conducive for patients with diabetes because it would allow the patients to be more cautious as to what is causing the insulin to be produced at a rapid pace. 1 doug said his doctor told him diabetes case study answers read more. This continuous over stimulation of insulin signaling alters how the insulin receptor and its down stream signaling pathways will respond to insulin. It can be phosphorylated by mapk at serine 307 and this prevents binding to the insulin receptor.

Case study 2 questions 1 7 what students are saying as a current student on this bumpy collegiate pathway i stumbled upon course hero where i can find study resources for nearly all my courses get online help from tutors 24 7 and even share my old projects papers and lecture notes with other students. His blood glucose level is 473. In this study elevated levels of glucose stimulate the release of insulin. In liver the forkhead transcription variable foxa2 activates transcription of genes regulating lipid metabolism and ketogenesis.

Elevated levels of insulin result in a decrease in blood glucose levels. Low blood glucose levels inhibit the release of insulin by the pancreatic cells. Wilson page 5 part ii diabetes and insulin signaling mia now that you understand the basics of signaling and the mechanisms it uses i want to talk about why this lab studies cellular signaling. Diabetes and insulin signaling case study answer key case solution.

National center for case study teaching in science diabetes and insulin signaling by kristy j.