Nephrogenic Diabetes Insipidus Pathophysiology

Key points nephrogenic diabetes insipidus ndi is caused by inability of the kidneys to concentrate urine by reabsorbing water in the collecting duct ndi can be inherited x linked or autosomal.

Nephrogenic diabetes insipidus pathophysiology. This genetic mutation is has an autosomal. Up to 20 of people taking lithium will develop nephrogenic. In most people the body balances the fluids you drink with the amount of urine. However people with nephrogenic diabetes insipidus produce too much urine polyuria which causes them to be excessively thirsty polydipsia.

The body normally balances fluid intake with the excretion of fluid in urine. Primary forms of ndi result from mutations in the genes that encode the. Pathophysiology diagnosis and management of nephrogenic diabetes insipidus pubmed healthy kidneys maintain fluid and electrolyte homoeostasis by adjusting urine volume and composition according to physiological needs. Nephrogenic diabetes insipidus ndi is a rare disorder that occurs when the kidneys are unable to concentrate urine.

Causes of nephrogenic diabetes insipidus familial or genetic causes resulting from mutation in the aqp2 gene that codes for the aquaporin 2 protein. In nephrogenic diabetes insipidus ndi inability of the kidneys to respond to avp results in functional aqp deficiency. Causes of nephrogenic diabetes insipidus in adults include. Nephrogenic diabetes insipidus is a disorder of water balance.

This also causes them to keep pushing fluids out of the body. The final urine composition is determined in the last tubular segment. Other medicines including demeclocycline declomycin ofloxacin floxin orlistat alli xenical and others. Consequently affected patients have constant diuresis resulting in large volumes of dilute urine.